AdipoUpX™ Human UCP3 Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human UCP3 Lentiviral Particle (Overexpression) is a powerful, high-titer gene delivery tool. It is specifically designed for the stable overexpression of the human UCP3 gene. The UCP3 protein is a key component for studying mitochondrial uncoupling and thermogenesis. Genome integration enables the establishment of stable cell lines. This product accelerates progress in metabolic research by enabling rapid validation of UCP3's effects on energy expenditure and mitochondrial protection. Customization of functional components, including promoters and markers, is highly flexible.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: UCP3

Full Name: Uncoupling protein 3

Gene Symbol: SLC25A9

Gene ID: 7352

RefSeq ID: NM_003356.4, NP_003347.1

Summary: UCP3 encodes a key mitochondrial inner membrane protein that operates as a proton leak channel. This protein's primary function is to uncouple oxidative phosphorylation from ATP synthesis, allowing the potential energy stored in the proton gradient to be dissipated directly as heat. While mainly expressed in skeletal muscle, UCP3 also acts as a mitochondrial safety valve: when fatty acid supply exceeds oxidation capacity, it facilitates the export of fatty acids, shielding mitochondria from lipid-induced oxidative stress. This process is vital for overall energy expenditure and metabolic flexibility.

AdipoUpX™ Human UCP3 Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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