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AdipoUpX™ Human BBS7 Lentiviral Particle (Overexpression)

Cat. No.: V1225XX443
Species: Human
Target Gene: BBS7
Vector System: Lentiviral
Modulation Type: Overexpression
AdipoUpX™ Human BBS7 Lentiviral Particle (Overexpression)
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Product Overview

Description: AdipoUpX™ Human BBS7 Lentiviral Particle (Overexpression) is professionally engineered for the efficient and stable expression of the human BBS7 gene, a core component of the BBSome. This stable integration tool is an ideal asset for studying ciliary protein trafficking and its impact on energy homeostasis. Every viral particle product is verified through comprehensive quality control (titer, sterility, and mycoplasma detection) to ensure safety. The lentivirus characteristic of genome integration enables the creation of permanent cell lines for high-fidelity functional validation.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.
Sterility Test: This product was certified sterile following successful microbial growth analysis.
Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.
Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.
Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.
Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.
Shipping Condition: Our lentivirus viral products are shipped using dry ice.
Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: BBS7
Full Name: Bardet-Biedl syndrome 7
Gene Symbol: BBS2L1
Gene ID: 55212
RefSeq ID-1: NP_060660.2
RefSeq ID-2: NM_018190.3
Summary: BBS7 encodes one of the eight core subunits (BBS1, BBS2, BBS4, BBS5, BBS7, BBS8, BBS9, and BBIP10) that form the crucial BBSome complex. The BBSome is a molecular coat complex believed to regulate the trafficking of signaling receptors to and from the primary cilium, promoting ciliogenesis. The assembly of this complex is mediated by the chaperonin-like BBS proteins (BBS6, BBS10, BBS12) and CCT/TRiC family chaperonins. Mutations in BBS7 are implicated in Bardet-Biedl syndrome (BBS), a disorder characterized by obesity, retinal degeneration, and nephropathy. However, mutations in BBS7 are generally considered to play a minor role compared to the chaperonin-like BBS genes, which are major contributors to disease development.

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