LipoKnoxa™ Human GDF15 shRNA Lentiviral Particle (Silencing)

Sub Cat. No.	TargetSeq	Region	Inquiry
V0126XX537-1	GCTCCAGACCTATGATGACTT	CDS	Inquiry
V0126XX537-2	AGACTCCAGATTCCGAGAGTT	CDS	Inquiry
V0126XX537-3	TCTCAGATGCTCCTGGTGTTG	CDS	Inquiry
V0126XX537-4	Other		Inquiry

Product Overview

Description: LipoKnoxa™ Human GDF15 shRNA Lentiviral Particle (Silencing) targets GDF15, an endocrine signal that suppresses appetite. Silencing this gene using our U6 or miR30-based systems assists in uncovering stress-induced metabolic signals. To ensure experimental success, all particles undergo comprehensive quality control, covering functional titer and mycoplasma.

Production Cell Line: HEK293T

Promoter: U6; CMV; EF1α; CAG; UBC

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Comprehensive sequencing and PCR analyses were performed to verify the accurate genomic sequence of all viral preparations.

Sterility Test: Confirmed sterile via rigorous microbial analysis; free of bacterial and fungal contamination.

Mycoplasma Test: Rigorous quality control testing has confirmed the absence of mycoplasma contamination in this viral preparation.

Other QC: Customized supplementary testing and in vitro/in vivo assessments are available to verify post-silencing gene expression and biological functionality, ensuring the viral preparations meet the specific potency requirements of your gene interference project.

Storage: Store at -80°C for long-term preservation. Immediate transfer upon delivery is required to prevent loss of viral activity.

Stability: Shelf life: 6–12 months at -80°C (extended stability up to 2 years). Post-thaw: Stable at 4°C for 2–3 weeks without significant degradation of functional titers.

Shipping Condition: Products are delivered on dry ice to maintain the cold chain. Upon arrival, please ensure the presence of dry ice and transfer the vials immediately to -80°C storage.

Handling Notes: Avoid repeated freeze-thaw cycles. Aliquot into low-protein-binding tubes immediately after receipt to maintain optimal activity. For safety and contamination control, all viral handling must be performed inside a biosafety cabinet.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: We ensure product integrity through rigorous QC, but we do not guarantee results in specific research contexts. Proper storage, handling, and total compliance with biosafety laws and safety protocols remain the sole responsibility of the user.

Target Profile

Gene Name: GDF15

Full Name: Growth differentiation factor 15

Gene Symbol: HG; PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15

Gene ID: 9518

RefSeq ID-1: NP_004855.2

RefSeq ID-2: NM_004864.4

Summary: GDF15 encodes a stress-induced, secreted cytokine belonging to the TGF-β superfamily. The protein acts as a systemic signal in response to cellular injury, inflammation, and metabolic stress. Elevated GDF15 levels have been associated with appetite suppression and weight regulation in pathological and metabolic conditions.

LipoKnoxa™ Human GDF15 shRNA Lentiviral Particle (Silencing)

Product Overview

Specification

Target Profile

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