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AdipoUpX™ Human IL6 MSCV Particle (Overexpression)

Cat. No.: V1225XX819
Species: Human
Target Gene: IL6
Vector System: MSCV Retrovirus
Modulation Type: Overexpression
AdipoUpX™ Human IL6 MSCV Particle (Overexpression)
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Mammalian Cell Selection:
Fluorescent Reporters:
Titer:
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Product Overview

Description: AdipoUpX™ Human IL6 MSCV Particle (Overexpression) is a stable integration tool for the specific and efficient overexpression of the human IL6 gene. IL6 is a versatile cytokine that modulates both inflammatory responses and metabolic signaling in obesity. This system is optimized for hematopoietic stem cells, stem cells, etc., making it an ideal tool for investigating immunometabolism in permanent cellular models. The viral system features a modular design for high flexibility, and every lot is verified through comprehensive quality control to ensure data integrity and reproducibility.
Production Cell Line: HEK293T
Promoter: Ubi; CMV; EF1a; Others
Product Availability: Produced Upon Order

Specification

Titer Test: qPCR
Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test: No microbial contamination was detected in any product.
Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition: Our MSCV retroviral products are shipped using dry ice.
Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: IL6
Full Name: Interleukin 6
Gene Symbol: CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
Gene ID: 3569
RefSeq ID-1: NP_000591.1
RefSeq ID-2: NM_000600.5
Summary: IL6 encodes a key pleiotropic cytokine responsible for orchestrating the acute phase response and chronic inflammation. Primarily synthesized and secreted by immune cells at sites of inflammation, IL6 acts systemically as an endogenous pyrogen (fever inducer) and promotes B cell maturation. It exerts its effects by binding to the IL6 receptor, triggering a cascade of inflammatory gene expression. Dysregulated IL6 activity is strongly implicated in a wide spectrum of inflammatory disorders, including systemic juvenile rheumatoid arthritis and increased susceptibility to diabetes mellitus. Elevated IL6 levels are also recognized as a key indicator of severe inflammatory load in viral infections like COVID-19.

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