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AdipoUpX™ Human GNAS MSCV Particle (Overexpression)
Cat. No.:
V1225XX821
Species:
Human
Target Gene:
GNAS
Vector System:
MSCV Retrovirus
Modulation Type:
Overexpression
SPECIFIC INQUIRY
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Product Overview
Description:
AdipoUpX™ Human GNAS MSCV Particle (Overexpression) is a high-titer, ready-to-use MSCV retroviral particle professionally engineered for the stable overexpression of the human GNAS gene. GNAS encodes the G-protein alpha subunit, a master regulator of cAMP signaling crucial for energy expenditure. Its vector structure is optimized for hematopoietic stem cells, stem cells, etc., ensuring high-level gene integration and long-term stability. Every batch is verified through comprehensive quality control—including titer, sterility, and mycoplasma detection—to ensure experimental safety and data reproducibility.
Production Cell Line:
HEK293T
Promoter:
Ubi; CMV; EF1a; Others
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test:
No microbial contamination was detected in any product.
Mycoplasma Test:
No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC:
Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage:
The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability:
Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition:
Our MSCV retroviral products are shipped using dry ice.
Handling Notes:
Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.
Target Profile
Gene Name:
GNAS
Full Name:
GNAS complex locus
Gene Symbol:
AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; PITA3; AIMAH1; C20orf45
Gene ID:
2778
RefSeq ID-1:
NP_001070958.1
RefSeq ID-2:
NM_001077490.3
Summary:
GNAS is a complex imprinted locus that produces multiple transcripts expressed maternally, paternally, or biallelically. These transcripts originate from four alternative promoters and 5' exons, with some containing differentially methylated regions (DMRs) that influence expression. The locus also generates antisense noncoding RNAs, which may regulate imprinting, and one transcript contains an overlapping open reading frame encoding the unrelated protein Alex. Alternative splicing yields various forms of the stimulatory G-protein alpha subunit, which links receptor-ligand interactions to adenylyl cyclase activation and downstream cellular responses, including pathways regulating energy balance and fat metabolism. Mutations or imprinting defects in GNAS are associated not only with disorders such as pseudohypoparathyroidism types 1a/1b, Albright hereditary osteodystrophy, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia, and some pituitary tumors, but can also lead to early-onset, monogenic obesity due to impaired G-protein signaling in hypothalamic energy-regulating pathways.
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