AdipoUpX™ Human GHRL MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human GHRL MSCV Particle (Overexpression) is a professionally engineered vector particle providing efficient and stable overexpression of human GHRL. The vector is optimized specifically for hematopoietic cells, stem cells, etc. This makes it an ideal tool for establishing stable cell lines to investigate the GHRL precursor protein, the source of ghrelin hunger signaling. Overexpressing GHRL facilitates investigation of its cleavage products and their role in appetite regulation and neuroendocrinology. The viral system features a modular design offering high flexibility.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: GHRL

Full Name: Ghrelin and obestatin prepropeptide

Gene Symbol: MTLRP

Gene ID: 51738

RefSeq ID: NM_001134941.3, NP_001128413.1

Summary: The GHRL gene dictates the production of the precursor for the "hunger hormone," ghrelin. Secreted by the stomach when empty, ghrelin acts as the only known circulating appetite stimulant, binding to the growth hormone secretagogue receptor in the hypothalamus to trigger both feeding behavior and the release of growth hormone. This peptide is central to the gut-brain axis regulation of energy balance, gastric motility, and reward perception. While the associated peptide, obestatin, was initially thought to be a satiety signal, both peptides' roles in appetite and glucose metabolism remain under intense investigation for potential anti-obesity therapies.

AdipoUpX™ Human GHRL MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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