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SR1664
Cat. No.:
0225LY-0818
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Add to basket
Product Overview
Description:
SR1664 is a potent and selective PPAR-gamma inhibitor with antidiabetic potential; it blocks Cdk5-mediated phosphorylation of PPAR-gamma (IC50: 80 nM) without acting as an agonist.
Synonym:
SR 1664; 1338259-05-4; SR-1664; 4'-[[2,3-Dimethyl-5-[[[(1S)-1-(4-nitrophenyl)ethyl]amino]carbonyl]-1H-indol-1-yl]methyl]-[1,1'-biphenyl]-2-carboxylicacid; 4'-[(2,3-Dimethyl-5-{[(1s)-1-(4-Nitrophenyl)ethyl]carbamoyl}-1h-Indol-1-Yl)methyl]biphenyl-2-Carboxylic Acid; 2-[4-[[2,3-dimethyl-5-[[(1S)-1-(4-nitrophenyl)ethyl]carbamoyl]indol-1-yl]methyl]phenyl]benzoic acid; (S)-4'-((2,3-dimethyl-5-((1-(4-nitrophenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid
CAS No.:
1338259-05-4
Compound CID:
53239854
Formula:
C33H29N3O5
Formula Weight:
547.6
Specification
Targets&IC50:
PPARγ: 28.67 nM(Ki); PPARγ: 80 nM
Relative Density:
1.27 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SR1664 can be used in diabetes research to study the non-agonistic ligand binding of PPAR gamma and its impact on insulin sensitivity.
Library Information
Target:
PPAR
Receptor:
PPARγ
Pathways:
Metabolism; DNA damage/DNA repair
Plate Number:
AOCL-11
Plate Location:
e7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
60 mg/mL; 109.57 mM
