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STL127705
Cat. No.:
OB0225WX-2275
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
STL127705 is a potent inhibitor of the Ku 70/80 heterodimer protein that disrupts Ku-DNA interactions (IC50: 3.5 μM) and suppresses Ku-dependent DNA-PKCS kinase activation.
Synonym:
Compound L; 7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione; 1326852-06-5; 7-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione; 2-[2-(3,4-dimethoxyphenyl)ethylamino]-6-(3-fluorophenyl)-8H-pyrimido[4,5-d]pyrimidine-5,7-dione; 7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione; 7-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-fluorophenyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazine-2,4-dione
CAS No.:
1326852-06-5
Compound CID:
53333307
Formula:
C22H20FN5O4
Formula Weight:
437.42
Specification
Targets&IC50:
Ku 70/80: 3.5 μM ; DNA-PKCS: 2.5 μM
Relative Density:
1.40 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
STL127705 is used in biochemical research to examine the targeted inhibition of specific protein kinases and their downstream impact on cellular proliferation and survival pathways.
Library Information
Target:
DNA-PK
Receptor:
DNA-PKCS; Ku 70/80 heterodimer protein
Pathways:
DNA damage/DNA repair; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-30
Plate Location:
b4
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
60 mg/mL; 137.17 mM
Water Max Solubility:
<0.1 mg/mL (insoluble)
