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Tuvusertib
Cat. No.:
0225LY-1290
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Tuvusertib is an orally available ATR kinase inhibitor that blocks CHK1 phosphorylation and disrupts DNA repair to induce apoptosis in tumor cells.
Synonym:
M1774; ATR inhibitor 1; 1613200-51-3; M-1774; M 1774; 2-Amino-6-fluoro-N-[5-fluoro-4-(1-methyl-1H-imidazol-5-yl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide; 2-amino-6-fluoro-N-[5-fluoro-4-(3-methylimidazol-4-yl)pyridin-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide; compound I-C-79 (WO2014089379A1); 2-amino-6-fluoro-N-(5-fluoro-4-(1-methyl-1H-imidazol-5-yl)pyridin-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide; 2-amino-6-fluoro-N-[5-fluoro-4-(1-methyl-1H-imidazol-5-yl)pyridin-3-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS No.:
1613200-51-3
Compound CID:
90199447
Formula:
C16H12F2N8
Formula Weight:
370.32
Specification
Relative Density:
1.68 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Tuvusertib can be used in DNA damage response research to study the potent and selective inhibition of ATR kinase.
Library Information
Target:
Chk; ATM/ATR
Receptor:
ATR; Chk1
Pathways:
DNA damage/DNA repair; Apoptosis; PI3K/Akt/mTOR signaling; Cell cycle/Checkpoint
Plate Number:
AOCL-17
Plate Location:
e7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
6.67 mg/mL; 18.01 mM
