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GW0742
Cat. No.:
0225LY-0879
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
GW0742 is a potent and specific PPARδ agonist, showing an EC50 of 1 nM for the human delta subtype compared to much higher values for the alpha and gamma subtypes.
Synonym:
317318-84-6; GW 0742; GW-0742; {4-[({2-[3-Fluoro-4-(Trifluoromethyl)phenyl]-4-Methyl-1,3-Thiazol-5-Yl}methyl)sulfanyl]-2-Methylphenoxy}acetic Acid; GW610742; GW0742X; GW-0742X; 2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy)acetic acid; 2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid; [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid; SR-05000000447; MFCD07369423
CAS No.:
317318-84-6
Compound CID:
9934458
Formula:
C21H17F4NO3S2
Formula Weight:
471.49
Specification
Targets&IC50:
PPARα: 1.1 μM; PPARγ: 2 μM; PPARδ: 1 nM
Relative Density:
1.462 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
GW0742 can be used in cellular biology to investigate the potent and selective activation of the PPAR delta isoform.
Library Information
Target:
PPAR
Receptor:
PPARα; PPARγ; PPARδ
Pathways:
Metabolism; DNA damage/DNA repair
Plate Number:
AOCL-12
Plate Location:
c8
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
250 mg/mL; 530.23 mM
ALogP:
5.795
HBA_Count:
3
HBD_Count:
0
Rotatable Bond:
8
