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CP-673451
Cat. No.:
0225LY-0766
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
CP-673451 is a specialized inhibitor of PDGFR-alpha/beta (IC50: 10/1 nM) that exhibits antiangiogenic and antitumor properties with 450-fold higher selectivity compared to other angiogenic receptors.
Synonym:
343787-29-1; 1-(2-(5-(2-Methoxyethoxy)benzimidazol-1-yl)quinolin-8-yl)piperidin-4-ylamine; 4-Piperidinamine, 1-(2-(5-(2-methoxyethoxy)-1H-benzimidazol-1-yl)-8-quinolinyl)-
CAS No.:
343787-29-1
Compound CID:
10158940
Formula:
C24H27N5O2
Formula Weight:
417.5
Specification
Targets&IC50:
PDGFRα: 10 nM; PDGFRβ: 1 nM
Relative Density:
1.32 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
CP-673451 can be used in oncology research to examine the selective inhibition of PDGFR and its role in suppressing tumor growth.
Library Information
Target:
VEGFR; PDGFR; c-Kit
Receptor:
c-Kit; PDGFRα; PDGFRβ; VEGFR1; VEGFR2
Pathways:
Angiogenesis; Tyrosine kinase/adaptors
Plate Number:
AOCL-10
Plate Location:
h3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
20.83 mg/mL; 49.89 mM
Ethanol Max Solubility:
41.8 mg/mL; 100.12 mM
