AdipoUpX™ Human TCF7L2 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human TCF7L2 MSCV Particle (Overexpression) is a high-titer, ready-to-use MSCV retroviral particle professionally engineered for the stable expression of the human TCF7L2 gene. This transcription factor is the most significant genetic risk factor for type 2 diabetes and regulates both GLP-1 secretion and adipogenesis. The vector structure is optimized for stem cells, hematopoietic stem cells, etc., ensuring consistent and high-level expression for genomic research. Every batch passes through exhaustive quality control to ensure data integrity.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: TCF7L2

Full Name: Transcription factor 7 like 2

Gene Symbol: TCF4; TCF-4

Gene ID: 6934

RefSeq ID-1: NP_001139746.1

RefSeq ID-2: NM_001146274.2

Summary: TCF7L2 encodes a transcription factor containing an HMG box and plays a central role in Wnt signaling. It is implicated in maintaining blood glucose levels, and genetic variants are associated with an increased risk of type 2 diabetes. Several transcript variants encoding different isoforms have been identified.

AdipoUpX™ Human TCF7L2 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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