AdipoUpX™ Human POMC Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human POMC Lentiviral Particle (Overexpression) is a high-titer system for the specific and stable expression of the human POMC gene. POMC is a precursor protein that generates key satiety signaling peptides like α-MSH. Its stable overexpression enables researchers to study post-translational modifications and the precise role in appetite suppression pathways. The lentivirus characteristic of genome integration establishes reliable cell models. Clients can freely customize key functional components to meet diverse experimental needs.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: POMC

Full Name: Pro-opiomelanocortin

Gene Symbol: LPH; MSH; NPP; POC; ACTH; CLIP; OBAIRH

Gene ID: 5443

RefSeq ID: NM_000939.4, NP_000930.1

Summary: The protein encoded by the POMC gene is one of the most complex peptide hormone precursors in the body. This precursor protein undergoes tissue-specific, intricate post-translational processing to yield up to ten bioactive peptides, including potent appetite suppressants (α-MSH), endorphins, adipokines, and ACTH. Differential processing of POMC peptides in the pituitary and hypothalamus confers their critical roles in energy homeostasis, adrenal function, and pain regulation. Furthermore, its mutations are associated with early-onset obesity, adrenal insufficiency, and distinctive hair pigmentation changes, reflecting its broad-spectrum effects across endocrine and neural systems.

AdipoUpX™ Human POMC Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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