Product Overview
Description:
AdipoUpX™ Human INPPL1 MSCV Particle (Overexpression) is a high-efficiency gene delivery tool for the stable expression of the SHIP2 protein, a key negative regulator of insulin signaling. This particle is an ideal resource for studying how lipid phosphatases contribute to obesity-linked insulin sensitivity defects. The MSCV system is specifically optimized for potent expression in hematopoietic stem cells, stem cells, and other mammalian cell lines. To maintain the highest standards of safety and data consistency, all particles are subjected to exhaustive quality control, encompassing titer measurement and mycoplasma testing.
Production Cell Line:
HEK293T
Promoter:
Ubi; CMV; EF1a; Others
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test:
No microbial contamination was detected in any product.
Mycoplasma Test:
No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC:
Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage:
The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability:
Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition:
Our MSCV retroviral products are shipped using dry ice.
Handling Notes:
Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.
Target Profile
Gene Name:
INPPL1
Full Name:
Inositol polyphosphate phosphatase like 1
Gene Symbol:
OPSMD; SHIP2
Summary:
INPPL1 encodes an SH2-domain-containing inositol phosphatase involved in insulin signaling regulation. It also influences epidermal growth factor receptor turnover and actin remodeling. Additionally, INPPL1 supports metastatic growth in breast cancer and serves as a biomarker for tumor progression.
