AdipoUpX™ Human TFAM MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human TFAM MSCV Particle (Overexpression) facilitates the stable expression of mitochondrial transcription factor A, a central regulator of mitochondrial DNA transcription and replication. This product is an excellent resource for investigating mitochondrial biogenesis and energy expenditure in obesity models. The MSCV vector is designed for efficient integration in hematopoietic stem cells, stem cells, and various mammalian cell lines. To guarantee experimental safety and reproducibility, all products undergo comprehensive quality control, including titer, sterility, and mycoplasma testing.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: TFAM

Full Name: Transcription factor A, mitochondrial

Gene Symbol: TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; MTDPS15

Gene ID: 7019

RefSeq ID-1: NP_001257711.1

RefSeq ID-2: NM_001270782.2

Summary: TFAM encodes a mitochondrial transcription factor containing two high-mobility group motifs. It is essential for mitochondrial DNA replication, transcription, and repair. Polymorphisms in TFAM are linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. Multiple transcript variants exist, and pseudogenes are present on chromosomes 6, 7, and 11.

AdipoUpX™ Human TFAM MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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