AdipoUpX™ Human DYRK1B MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human DYRK1B MSCV Particle (Overexpression) is a high-titer, ready-to-use MSCV retroviral particle professionally engineered for the stable expression of the human DYRK1B gene. Mutations in this kinase are associated with truncal obesity and metabolic syndrome. The MSCV vector is optimized for hematopoietic stem cells, stem cells, etc., ensuring high-level gene integration for studying the switch between adipogenesis and myogenesis. Product quality is ensured by rigorous purification and comprehensive QC screening, ensuring experimental results are repeatable, safe, and accurate.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: DYRK1B

Full Name: Dual specificity tyrosine phosphorylation regulated kinase 1B

Gene Symbol: MIRK; AOMS3

Gene ID: 9149

RefSeq ID-1: NP_004705.1

RefSeq ID-2: NM_004714.3

Summary: DYRK1B encodes a nuclear-localized protein kinase of the DYRK family, involved in regulating fundamental processes like the cell cycle. While alterations in its expression are sometimes found in tumor cells, its most distinctive clinical consequence involves metabolic health: identified mutations in DYRK1B are a direct cause of Abdominal Obesity-Metabolic Syndrome 3. This rare disorder reveals a clear functional link where the kinase's role in cellular control pathways directly drives the pathological development of central obesity and associated severe metabolic dysfunction.

AdipoUpX™ Human DYRK1B MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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