AdipoUpX™ Human ARL6 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ARL6 MSCV Particle (Overexpression) is a powerful gene delivery tool designed for the efficient, stable expression of the human ARL6 (BBS3) gene. This GTPase is responsible for the recruitment of the BBSome to primary cilia. The vector structure is optimized for stem cells, hematopoietic stem cells, etc., ensuring stable, high-level gene integration. This product is an ideal tool for investigating ciliary trafficking defects and is backed by comprehensive quality control to ensure experimental performance and data safety.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: ARL6

Full Name: ARF like GTPase 6

Gene Symbol: BBS3; RP55

Gene ID: 84100

RefSeq ID-1: NP_001265222.1

RefSeq ID-2: NM_001278293.3

Summary: ARL6 encodes a GTP-binding protein of the ARF-like family involved in intracellular trafficking and ciliary function. It facilitates proper BBSome localization and ciliogenesis. Mutations in ARL6 are linked to Bardet–Biedl syndrome, a condition often associated with obesity, retinal degeneration, and renal defects. A vision-specific transcript, BBS3L, encodes a longer isoform important for retinal function.

AdipoUpX™ Human ARL6 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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