AdipoUpX™ Human VPS13B MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human VPS13B MSCV Particle (Overexpression) is a high-titer, ready-to-use MSCV retroviral particle professionally engineered for the stable expression of the human VPS13B gene. Mutations in this gene cause Cohen syndrome, which includes a predisposition to trunk obesity. The vector structure is optimized for hematopoietic stem cells, stem cells, embryonic types, etc., ensuring stable, high-level gene integration. Every batch undergoes comprehensive quality control (titer, sterility, and mycoplasma testing) to ensure that the results are safe and repeatable.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: VPS13B

Full Name: Vacuolar protein sorting 13 homolog B

Gene Symbol: CHS1; COH1; BLTP5B

Gene ID: 157680

RefSeq ID-1: NP_056058.2

RefSeq ID-2: NM_015243.2

Summary: VPS13B encodes a putative transmembrane protein involved in vesicle-mediated transport and intracellular protein sorting. It is implicated in the development and function of the eye, hematological system, and central nervous system. Mutations in VPS13B are linked to Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified.

AdipoUpX™ Human VPS13B MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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