AdipoUpX™ Human LZTFL1 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human LZTFL1 MSCV Particle (Overexpression) is a powerful gene delivery tool designed for the specific and efficient stable expression of the human LZTFL1 gene. This protein is involved in ciliary protein trafficking, and its dysfunction is linked to Bardet-Biedl syndrome and obesity. The MSCV backbone is tailored for stem cells, hematopoietic stem cells, etc., making it an ideal tool for investigating ciliopathy-related metabolic defects. Our viral system supports flexible selection of reporter genes and undergoes comprehensive quality control to ensure total reliability and safety.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: LZTFL1

Full Name: Leucine zipper transcription factor like 1

Gene Symbol: BBS17

Gene ID: 54585

RefSeq ID-1: NP_001263307.1

RefSeq ID-2: NM_001276378.2

Summary: LZTFL1 encodes a widely expressed cytoplasmic protein that interacts with Bardet–Biedl syndrome (BBS) proteins to control ciliary membrane protein trafficking. Nonsense mutations result in BBS, a disorder featuring obesity, polydactyly, cognitive impairment, hypogonadism, and kidney abnormalities. LZTFL1 may also act as a tumor suppressor by regulating epithelial-to-mesenchymal transitions through E-cadherin and actin cytoskeleton interactions.

AdipoUpX™ Human LZTFL1 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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