AdipoUpX™ Human BDNF MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human BDNF MSCV Particle (Overexpression) is a powerful gene delivery tool designed for the efficient, stable overexpression of the human BDNF gene. BDNF is a critical neurotrophin that suppresses food intake and enhances energy expenditure. The vector structure is optimized for hematopoietic stem cells, stem cells, etc., allowing for the establishment of stable lines to study neuroplasticity. Every batch undergoes comprehensive quality control, including titer and sterility testing, to ensure that the experimental results are safe and highly reproducible.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: BDNF

Full Name: Brain derived neurotrophic factor

Gene Symbol: ANON2; BULN2

Gene ID: 627

RefSeq ID-1: NP_001137277.1

RefSeq ID-2: NM_001143805.1

Summary: BDNF is a member of the neurotrophin family, synthesized initially as a preproprotein that requires specific cleavage to become the active, mature signaling molecule. Its function is essential for the lifelong health of the nervous system: binding of BDNF to its receptor (TrkB) promotes the survival, growth, and proper functioning of neurons in the adult brain. This protein is a central player in regulating the adaptive response to stress and is strongly implicated in the pathology of mood disorders. Furthermore, reduced BDNF expression is a consistent molecular finding in patients with severe neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease.

AdipoUpX™ Human BDNF MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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