AdipoUpX™ Human GHSR MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human GHSR MSCV Particle (Overexpression) is a professionally engineered MSCV particle designed for the stable expression of the growth hormone secretagogue receptor (the ghrelin receptor). This tool is vital for investigating the molecular mechanisms of hunger signaling and growth hormone release in metabolic studies. The vector is optimized for use in hematopoietic stem cells, stem cells, and other mammalian cell lines, facilitating the creation of stable cell lines. Comprehensive quality control, including titer, sterility, and mycoplasma testing, is performed to ensure experimental safety and reproducibility.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: GHSR

Full Name: Growth hormone secretagogue receptor

Gene Symbol: GHDP; GHS-R1a; GHSR-1a

Gene ID: 2693

RefSeq ID-1: NP_004113.1

RefSeq ID-2: NM_004122.2

Summary: The GHSR gene encodes a G-protein-coupled receptor that serves as the specific target for ghrelin. It defines a crucial neuroendocrine pathway for growth hormone release and the regulation of energy homeostasis. While the 1a isoform acts as the functional ghrelin receptor to stimulate hunger, the 1b transcript may serve as a regulatory inhibitor, balancing appetite and weight.

AdipoUpX™ Human GHSR MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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