AdipoUpX™ Human ADRB2 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human ADRB2 MSCV Particle (Overexpression) is a powerful gene delivery tool designed for the efficient and stable overexpression of the human ADRB2 gene. This receptor is vital for catecholamine-induced lipolysis and thermogenic regulation. The MSCV system is specifically tailored to drive robust expression in hematopoietic stem cells, stem cells, and other mammalian lineages, making it an ideal tool for establishing permanent cell lines. The viral system features a modular design for high flexibility, and all products undergo rigorous quality control to ensure consistency.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: ADRB2

Full Name: Adrenoceptor beta 2

Gene Symbol: BAR; ARB2; B2AR; ADRBR; ADRB2R; BETA2AR

Gene ID: 154

RefSeq ID-1: NP_000015.2

RefSeq ID-2: NM_000024.6

Summary: ADRB2 encodes the beta-2-adrenergic receptor, a member of the G protein-coupled receptor family. It forms a signaling complex with the L-type calcium channel Ca(V)1.2, G proteins, adenylyl cyclase, cAMP-dependent kinase, and PP2A phosphatase, ensuring rapid and specific signal transduction. In addition to its classical signaling role, ADRB2 can regulate alpha-synuclein transcription, a pathway implicated in Parkinson’s disease. The gene is intronless, and polymorphisms, point mutations, or downregulation are associated with nocturnal asthma, obesity, type 2 diabetes, and cardiovascular disease.

AdipoUpX™ Human ADRB2 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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