Product Overview
Description:
AdipoUpX™ Human ADRB3 MSCV Particle (Overexpression) is a stable integration tool for the specific and efficient overexpression of the human ADRB3 gene. ADRB3 is the key receptor regulating lipolysis and thermogenesis. This product allows systematic investigation into ADRB3-mediated catecholamine signaling and its impact on energy expenditure. It serves as a powerful tool for in vitro functional validation and signaling studies. The product is ready-to-use, and all viral systems undergo rigorous testing to ensure quality.
Production Cell Line:
HEK293T
Promoter:
Ubi; CMV; EF1a; Others
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test:
No microbial contamination was detected in any product.
Mycoplasma Test:
No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC:
Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage:
The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability:
Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition:
Our MSCV retroviral products are shipped using dry ice.
Handling Notes:
Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.
Target Profile
Gene Name:
ADRB3
Full Name:
Adrenoceptor beta 3
Gene Symbol:
BETA3AR
Summary:
ADRB3 encodes the beta-3 adrenergic receptor, a G protein-coupled receptor found mainly on the surface of adipose cells. Activation of this receptor by catecholamines (such as norepinephrine) signals the cells to initiate lipolysis (fat breakdown) and thermogenesis (heat production) in brown and beige fat. ADRB3 is therefore a crucial pharmacological target for enhancing energy expenditure. Polymorphisms in the ADRB3 gene are frequently studied, as they are associated with individual differences in basal metabolic rate and susceptibility to obesity and type 2 diabetes.
