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Siramesine hydrochloride
Cat. No.:
0225LY-1429
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Siramesine hydrochloride is a selective agonist of the sigma-2 receptor that shows strong anticancer potential by inducing cell death in specific cancer models.
Synonym:
Lu 28-179 hydrochloride; 224177-60-0; Siramesine (hydrochloride); Siramesine HCl; SiraMesine, Lu-28-179; Siramesine (lu-28-179); 1'-(4-(1-(4-Fluorophenyl)-1H-indol-3-yl)butyl)-3H-spiro[isobenzofuran-1,4'-piperidine] hydrochloride; 1/'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4/'-piperidine];hydrochloride; Spiro(isobenzofuran-1(3H),4'-piperidine), 1'-(4-(1-(4-fluorophenyl)-1H-indol-3-yl)butyl)-, hydrochloride (1:1)
CAS No.:
224177-60-0
Compound CID:
9891778
Formula:
C30H32ClFN2
Formula Weight:
491.04
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Siramesine hydrochloride can be used in cancer research to study the induction of lysosomal membrane permeabilization and cell death in tumor cells.
Library Information
Target:
Sigma receptor; Ferroptosis regulator
Receptor:
Ferroptosis; Lysosome-destabilizing agent; Sigma-2 receptor
Pathways:
Apoptosis; GPCR/G protein signaling; Autophagy
Plate Number:
AOCL-19
Plate Location:
d2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
27.5 mg/mL; 56 mM
