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EF24
Cat. No.:
OB0225WX-1625
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
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Product Overview
Description:
EF24 is a 4-piperidinone derivative that acts as an inhibitor of the MAPK/ERK signaling axis, resulting in the downregulation of phosphorylated MEK1 and ERK and the concurrent activation of caspases 3 and 9.
Synonym:
EF 24; EF-24; 3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone; 342808-40-6; 3,5-bis(2-fluorobenzylidene)piperidin-4-one; (3E,5E)-3,5-Bis((2-fluorophenyl)methylene)-4-piperidinone; 4-Piperidinone, 3,5-bis((2-fluorophenyl)methylene)-, (3E,5E)-; 3,5-bis(2-flurobenzylidene) piperidin-4-one; (3E,5E)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one; (3e,5e)-3,5-bis(2-fluorobenzylidene)piperidin-4-one; 4-Piperidinone, 3,5-bis[(2-fluorophenyl)methylene]-, acetate, (3E,5E)-
CAS No.:
342808-40-6
Compound CID:
9885748
Formula:
C19H15F2N
Formula Weight:
311.33
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
EF24 is utilized in molecular pharmacology as a synthetic curcumin analog to study its enhanced bioavailability and its potent activity in inducing cell cycle arrest and apoptosis in cancer models.
Library Information
Target:
MEK; Caspase; ERK
Receptor:
Caspase-3; Caspase-9; ERK; MEK1
Pathways:
Apoptosis; MAPK; Proteases/Proteasome
Plate Number:
AOCL-21
Plate Location:
g10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
25 mg/mL; 80.3 mM
