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Si5-N14
Cat. No.:
OB0626WX-3678
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR and HPLC.
Size:
Add to basket
Product Overview
Description:
Si5-N14 is a siloxane-incorporated ionizable cationic lipidoid engineered to assemble highly efficient lipid nanoparticles for delivering linear and single-guide RNA platforms. The integration of siloxane groups into the hydrophobic domain alters membrane fluidity, boosting cellular internalization via micropinocytosis and lipid raft pathways while accelerating endosomal escape within microvascular endothelial networks. Systemically, it directs particle accumulation toward the lungs, achieving precise target knockdown without inducing acute inflammatory cytokine release.
Synonyms:
3,3’,3’’,3’’’-(((1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-tetradecylpropanamide); 3-[3-[[3-[bis[3-oxo-3-(tetradecylamino)propyl]amino]propyl-dimethylsilyl]oxy-dimethylsilyl]propyl-[3-oxo-3-(tetradecylamino)propyl]amino]-N-tetradecylpropanamide; 3006860-57-4
CAS No.:
3006860-57-4
Compound CID:
170571532
Formula:
C78H160N6O5Si2
Formula Weight:
1318.3
Specification
Solubility in Ethanol:
1-10 mg/mL
Storage:
Storage at -20°C.
Applications:
Si5-N14 supports research on functional lipid materials and lipid nanoparticle formulations. It can be used for investigating lipid structure optimization, nanoparticle composition, and the contribution of specialized lipid components to delivery system development.