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4A3-SCC-10
Cat. No.:
OB0626WX-3720
Appearance:
Liquid
Purity:
≥90%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
4A3-SCC-10 is a biodegradable ionizable cationic lipid featuring an apparent pKa of 6.22 and a responsive intramacromolecular disulfide bridge. This redox-sensitive linkage undergoes rapid intracellular cleavage, significantly enhancing endosomal escape and cargo release dynamics relative to non-disulfide controls. Following systemic administration, this specialized lipid matrix drives efficient nucleic acid delivery and selectively concentrates within hepatic tissue architectures.
Synonyms:
((methylazanediyl)bis(propane-3,1-diyl))bis(8,14-dioxo-7,15-dioxa-3,4,18,19-tetrathia-11-azahenicosane-11,1,21-triyl) tetrakis(3-(decylthio)-2-methylpropanoate); 3082361-42-7
CAS No.:
3082361-42-7
Compound CID:
172871932
Formula:
C91H171N3O16S12
Formula Weight:
1948.1
Specification
Solubility in Ethanol:
1-10 mg/mL
Storage:
Storage at -80°C.
Applications:
4A3-SCC-10 is utilized in lipid nanoparticle formulation studies as a functional lipid component for investigating delivery system characteristics. It supports research on lipid composition, nanoparticle engineering, and structure–function relationships of lipid materials.