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SANT-1
Cat. No.:
0225LY-0545
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
SANT-1 inhibits the effects of Smo agonists (IC50: 20 nM) by binding directly to the Smoothened (Smo) receptor with a dissociation constant (Kd) of 1.2 nM.
Synonym:
SANT 1; 304909-07-7; 1-Piperazinamine, N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-; (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine; N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
CAS No.:
304909-07-7
Compound CID:
6878030
Formula:
C23H27N5
Formula Weight:
373.49
Specification
Targets&IC50:
Smo receptor: 1.2 Nm
Relative Density:
1.13 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SANT-1 can be used in cellular biology to investigate the direct antagonism of Smoothened-mediated Hedgehog signaling.
Library Information
Target:
Smo
Receptor:
Smo
Pathways:
GPCR/G protein signaling; Stem cell regulation
Plate Number:
AOCL-8
Plate Location:
a9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
18.7 mg/mL; 50.07 mM
Ethanol Max Solubility:
9.3 mg/mL; 24.9 mM
Solubility:
Soluble in chloroform.
ALogP:
3.759
HBA_Count:
2
HBD_Count:
0
Rotatable Bond:
5
