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Sonidegib
Cat. No.:
0225LY-0549
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Sonidegib is a Smoothened (Smo) antagonist that suppresses Hedgehog (Hh) signaling with IC50 values of 1.3 nM and 2.5 nM in mice and humans, respectively.
Synonym:
Erismodegib; NVP-LDE225; LDE225; 956697-53-3; N-(6-((2S,6R)-2,6-Dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide; N-(6-((cis-2,6-Dimethylmorpholin-4-yl)-3-pyridyl)-2-methyl-3-(4-(trifluoromethoxy)phenyl)benzamide; N-(6-((2R,6S)-2,6-Dimethylmorpholin-4-yl)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide
CAS No.:
956697-53-3
Compound CID:
24775005
Formula:
C26H26F3N3O3
Formula Weight:
485.5
Specification
Targets&IC50:
Smo (human): 2.5 nM; Smo (mouse): 1.3 nM
Relative Density:
1.255 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Sonidegib can be used in dermatology and oncology research to examine its efficacy in treating basal cell carcinoma via Smoothened inhibition.
Library Information
Target:
Smo
Receptor:
Smo
Pathways:
Hedgehog signaling; Stem cell regulation; Developmental biology
Plate Number:
AOCL-8
Plate Location:
b3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
255 mg/mL; 525.23 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
90 mg/mL; 185.38 mM
ALogP:
6.732
HBA_Count:
4
HBD_Count:
1
Rotatable Bond:
6
