Products
Online Inquiry
Ophiobolin A
Cat. No.:
OB0626WX-2574
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by HPLC.
Size:
Add to basket
Product Overview
Description:
Calmodulin is a highly conserved, ubiquitous calcium-sensing protein that coordinates a wide array of downstream metabolic and signaling enzymes in response to cellular calcium fluxes. The fungal sesterterpenoid phytotoxin ophiobolin A acts as an irreversible antagonist of this calcium-binding protein, forming covalent bonds with highly conserved lysine residues across animal and plant variants to completely block calmodulin-dependent phosphodiesterase activation.
Synonyms:
(2'S,3'S,3aR,5'R,6aS,9R,9aS,10aR)-1,3a,4,4',5',6a,7,8,9,9a,10,10a-dodecahydro-9-hydroxy-3',9,10a-trimethyl-5'-spiro[dicyclopenta[a,d]cyclooctene-3(2H),2'(3'H)-furan]-6-carboxaldehyde; Cochliobolin; Ophiobolin; (1'R,2S,3S,3'S,4'R,5R,7'S,8'E,11'R)-4'-hydroxy-1',3,4'-trimethyl-5-(2-methylprop-1-enyl)-6'-oxospiro[oxolane-2,12'-tricyclo[9.3.0.03,7]tetradec-8-ene]-8'-carbaldehyde; (+)-Ophiobolin A; (18R)-14,18-epoxy-3-hydroxy-5-oxoophiobola-7,19-dien-25-al; 4611-05-6
CAS No.:
4611-05-6
Compound CID:
5281387
Formula:
C25H36O4
Formula Weight:
400.6
Specification
Source:
Bipolaris leersia
Solubility in DMSO:
Soluble
Solubility in Ethanol:
Soluble
Solubility in DMF:
Soluble
Solubility in Other Solvents:
Soluble in methanol.
Storage:
Storage at -20°C.
Applications:
Ophiobolin A serves as a research compound for investigating fungal-derived bioactive metabolites and their molecular interactions. It supports chemical biology studies, structural analysis, and investigations of small-molecule effects in biochemical research systems.
