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NVP-BHG712
Cat. No.:
0225LY-0538
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
NVP-BHG712 is a selective EphB4 inhibitor (ED50 = 25 nM) that can distinguish between EphB4 and VEGFR; it also inhibits c-Abl, c-Src, and c-Raf at higher concentrations.
Synonym:
940310-85-0; 4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide; Benzamide, 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]-
CAS No.:
940310-85-0
Compound CID:
16747388
Formula:
C26H20F3N7O
Formula Weight:
503.48
Specification
Targets&IC50:
EphB4: 25 nM; C-Raf: 0.395 μM; c-Src: 1.266 μM; c-ABL: 1.667 μM
Relative Density:
1.41 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
NVP-BHG712 can be used in Eph receptor research to study the selective inhibition of EphB4 signaling in vascular and tumor development.
Library Information
Target:
Raf; Bcr-Abl; Src; Ephrin receptor
Receptor:
c-Abl; c-Raf; c-Src; EphB4; Ephrin receptor
Pathways:
MAPK; Cytoskeletal signaling; Angiogenesis; Tyrosine kinase/adaptors
Plate Number:
AOCL-8
Plate Location:
a2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
24.7 mg/mL; 49.06 mM
ALogP:
4.871
HBA_Count:
5
HBD_Count:
2
Rotatable Bond:
6
