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Locostatin
Cat. No.:
OB0225WX-2314
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
Locostatin is a cell-permeable small molecule that functions by inhibiting the interaction between Raf1 kinase and the Raf kinase inhibitor protein (RKIP).
Synonym:
133812-16-5; (S)-4-Benzyl-3-(but-2-enoyl)oxazolidin-2-one; (E/Z)-Locostatin; (N-Crotonyl)-(4S)-benzyl-2-oxazolidinone; (4S)-4-benzyl-3-[(E)-but-2-enoyl]-1,3-oxazolidin-2-one; Cell Sheet Migration Inhibitor, Locostatin; (S,E)-4-benzyl-3-but-2-enoyloxazolidin-2-one; (4S)-N-Crotonyl-4-benzyl-2-oxazolidinone; (4S)-4-benzyl-3-((E)-but-2-enoyl)-1,3-oxazolidin-2-one; MFCD00278769; (S)-(+)-4-Benzyl-3-crotonyl-2-oxazolidi; (s)-3-((e)-but-2-enoyl)-4-benzyloxazolidinone; (4S)-3-((E)-2-butenoyl)-4-benzyl-2-oxazolidinone; (S)-3-(1-Oxo-2-butenyl)-4-(phenylmethyl)-2-oxazolidinone; (4S)-3-(1-Oxo-2-buten-1-yl)-4-(phenylmethyl)-2-oxazolidinone
CAS No.:
133812-16-5
Compound CID:
5702600
Formula:
C14H15NO3
Formula Weight:
245.27
Specification
Relative Density:
1.205 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Locostatin is used in cell biology research as a specialized chemical probe to investigate the inhibition of Raf Kinase Inhibitor Protein (RKIP) and its role in modulating cellular migration and signaling.
Library Information
Target:
Raf
Receptor:
Raf-1
Pathways:
MAPK
Plate Number:
AOCL-30
Plate Location:
f4
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
50 mg/mL; 203.86 mM
Ethanol Max Solubility:
10 mg/mL
Special Max Solubility:
DMF: 5 mg/mL
