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PRT062607 hydrochloride
Cat. No.:
0225LY-1105
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
PRT062607 hydrochloride is a selective Syk inhibitor with a 1 nM IC50, demonstrating a minimum of 80-fold higher affinity for Syk compared to other kinases.
Synonym:
PRT062607 (P505-15, BIIB057) HCl; P505-15 Hydrochloride; 1370261-97-4; PRT062607 HCl; PRT062607 (Hydrochloride); 5-Pyrimidinecarboxamide, 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-, hydrochloride (1:1); 2-[[(1R,2S)-2-aminocyclohexyl]amino]-4-[3-(triazol-2-yl)anilino]pyrimidine-5-carboxamide;hydrochloride; P505-15; PRT062607 (P505-15) HCl; BIIB-057; 4-((3-(2H-1,2,3-Triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide hydrochloride; P505-15 hydrochloride; 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide hydrochloride
CAS No.:
1370261-97-4
Compound CID:
56948527
Formula:
C19H23N9O·HCl
Formula Weight:
429.91
Specification
Targets&IC50:
MLK1: 88 nM (cell free); Syk: 1 nM (cell free); FGR: 81 nM (cell free)
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
PRT062607 hydrochloride can be used in hematology research to investigate the selective inhibition of Spleen Tyrosine Kinase (Syk).
Library Information
Target:
MLK; Src; Syk
Receptor:
FGR; MLK1; Syk
Pathways:
MAPK; Tyrosine kinase/adaptors; Angiogenesis
Plate Number:
AOCL-15
Plate Location:
b11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
250 mg/mL; 581.52 mM
Water Max Solubility:
79 mg/mL; 183.76 mM
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
