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Lonafarnib
Cat. No.:
OB0225LY-0059
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by HPLC and LC-MS.
Size:
Product Overview
Description:
Lonafarnib is a small molecule reagent that belongs to the group of farnesyltransferase inhibitors, which are mainly used to block the process of farnesylation in cells, thus inhibiting the growth of many types of cancer cells.
Synonym:
Sarasar; Sch66336; 193275-84-2; (+)-4-(2-(4-(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)-piperidin-1-yl))-2-oxoethyl)-piperidine-1-carboxamide; 4-(2-(4-((11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide; 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide
CAS No.:
193275-84-2
Compound CID:
148195
Formula:
C27H31Br2ClN4O2
Formula Weight:
638.82
Specification
Relative Density:
1.536 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Lonafarnib can be used to inhibit FPTase.
Library Information
Targets:
Ras; Raf; Autophagy; Transferase
Receptors:
Autophagy; Farnesyl Transferase; H-ras; K-ras-4B; N-ras; Ras
Pathways:
MAPK; GPCR/G protein; Autophagy; Metabolism
Plate Number:
AOCL-1
Plate Location:
f11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
10 mg/mL; 15.6 mM
