MRTX-1257

Cat. No.: OB0225WX-1894

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

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Product Overview

Description: MRTX-1257 is a covalent and selective inhibitor of KRAS G12C that suppresses KRAS-dependent ERK phosphorylation with an IC50 of 900 pM and exhibits approximately 31% bioavailability in vivo.

Synonym: 2206736-04-9; MRTX1257; 2-[(2S)-4-[7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile; (2S)-1-(1-Oxo-2-propen-1-yl)-4-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-2-piperazineacetonitrile; 2-((S)-1-Acryloyl-4-(7-(8-methylnaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile; 2-[(2S)-4-[7-(8-methylnaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-yl]-1-(prop-2-enoyl)piperazin-2-yl]acetonitrile; 2-[(2S)-4-[7-(8-methylnaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5H,6H,8H-pyrido[3,4-d]pyrimidin-4-yl]-1-(prop-2-enoyl)piperazin-2-yl]acetonitrile

CAS No.: 2206736-04-9

Compound CID: 134326084

Formula: C₃₃H₃₉N₇O₂

Formula Weight: 565.71

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: MRTX-1257 is utilized in laboratory research as a potent covalent inhibitor of KRAS G12C to study the rapid and irreversible inactivation of mutant KRAS-driven cellular growth.