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Jolkinolide B
Cat. No.:
0225LY-0584
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Jolkinolide B is a diterpene bioactive isolated from Euphorbia fischeriana Steud. that triggers apoptosis in cancer cells and is used to study the prevention and treatment of osteolysis.
Synonym:
37905-08-1; (1S,3R,8R,10R,11R,12R,17R)-5,12,16,16-tetramethyl-2,7,9-trioxahexacyclo[9.8.0.01,3.04,8.08,10.012,17]nonadec-4-en-6-one; (4aR,6aS,7aR,10aR,11aR,11bR,11cR)-4,4,8,11c-tetramethyl-1,2,3,4,4a,5,6,11a,11b,11c-decahydrobis(oxireno)[2',3':1,10a;2'',3'':3,4]phenanthro[3,2-b]furan-9(7aH)-one
CAS No.:
37905-08-1
Compound CID:
161954
Formula:
C20H26O4
Formula Weight:
330.42
Specification
Relative Density:
1.28 g/cm3 at 20°C.
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Jolkinolide B can be used in cancer biology to study the induction of apoptosis and the inhibition of the NF-kappaB signaling pathway.
Library Information
Target:
STAT; JNK; mTOR; Akt; PI3K; Caspase; NF-κB; p38 MAPK; IL receptor; BCL; JAK; ERK; TNF
Receptor:
Akt; Bcl-2; Caspase; ERK; IL receptor; JAK; JNK; mTOR; NF-κB; p38 MAPK; PI3K; STAT; TNF-α
Pathways:
MAPK; Immunology/Inflammation; NF-κB; Cytoskeletal signaling; Apoptosis; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem cell regulation; Proteases/Proteasome; Tyrosine kinase/adaptors
Plate Number:
AOCL-8
Plate Location:
e9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
3.31 mg/mL; 10.02 mM
