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Pluripotin
Cat. No.:
0225LY-0800
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
Pluripotin is a dual inhibitor of RasGAP and extracellular signal-regulated kinase 1 (ERK1, MAPK3) that facilitates the self-renewal of embryonic stem cells (ESCs).
Synonym:
839707-37-8; N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide; N-[3-[7-(2,5-Dimethyl-2H-pyrazol-3-ylamino)-1-methyl-2-oxo-1,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide
CAS No.:
839707-37-8
Compound CID:
12003241
Formula:
C27H25F3N8O2
Formula Weight:
550.53
Specification
Targets&IC50:
RasGAP: 212 nM(Kd); ERK1: 98 nM(Kd)
Relative Density:
1.43 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Pluripotin can be used in stem cell research to investigate the maintenance of embryonic stem cell self-renewal without the need for feeder layers or exogenous growth factors.
Library Information
Target:
S6 Kinase; ERK; Raf
Receptor:
ERK1; RasGAP; RSK
Pathways:
MAPK; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-11
Plate Location:
c9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
13.8 mg/mL; 25.07 mM
ALogP:
4.789
HBA_Count:
5
HBD_Count:
2
Rotatable Bond:
6
