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Lipid 5
Cat. No.:
OB0626WX-3947
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
Lipid 5 is an ionizable cationic amino lipid possessing a defined pKa of 6.56, engineered as a principal matrix component for the assembly of responsive transcript delivery vectors. The precise chemical structure optimizes low-pH oligonucleotide complexation and subsequent membrane fusion within acidic compartments, driving highly efficient endosomal escape to significantly elevate circulating levels of target secretory proteins in vivo.
Synonyms:
8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-octanoic acid, 1-octylnonyl ester; LIPIDV 004; Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate; 1-Octylnonyl 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]octanoate; nonyl 8-[(8-heptadecan-9-yloxy-8-octyl)-(2-hydroxyethyl)amino]octanoate; Octanoic acid, 8-[(2-hydroxyethyl)[8-(nonyloxy)-8-oxooctyl]amino]-, 1-octylnonyl ester; 2089251-33-0
CAS No.:
2089251-33-0
Compound CID:
126697428
Formula:
C44H87NO5
Formula Weight:
710.2
Specification
Solubility in Ethanol:
100 mg/mL
Storage:
Storage at -20°C.
Applications:
Lipid 5 serves as a synthetic ionizable lipid for lipid nanoparticle formulation and nucleic acid delivery studies. It supports formulation optimization, comparative screening of delivery lipids, and investigation of lipid structural features associated with nanoparticle performance.
