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A12-Iso5-2DC18
Cat. No.:
OB0626WX-3870
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
A12-Iso5-2DC18 is an ionizable cationic lipidoid featuring tailored hydrophobic tails and a pH-sensitive core, synthesized to function as a primary encapsulation matrix for non-viral nucleic acid transport. The molecular architecture is optimized to maintain a neutral surface charge under physiological conditions while facilitating rapid endosomal destabilization, promoting robust intracellular expression of encapsulated reporter transcripts.
Synonyms:
1-[3-(dimethylamino)propyl]-5,5-di-(8Z)-8-heptadecen-1-yl-2,5-dihydro-1H-imidazole-2-carboxylic acid, ethyl ester; 2412492-06-7; ethyl 1-[3-(dimethylamino)propyl]-5,5-bis[(Z)-heptadec-8-enyl]-2H-imidazole-2-carboxylate; Ethyl 1-(3-(dimethylamino)propyl)-5,5-di((Z)-heptadec-8-en-1-yl)-2,5-dihydro-1H-imidazole-2-carboxylate
CAS No.:
2412492-06-7
Compound CID:
146426091
Formula:
C45H85N3O2
Formula Weight:
700.2
Specification
Solubility in Ethanol:
Soluble in ethanol.
Storage:
Storage at -20°C.
Applications:
A12-Iso5-2DC18 serves as an experimental ionizable lipid for lipid nanoparticle formulation and delivery optimization. It supports structure–activity relationship studies, formulation screening, physicochemical characterization, and evaluation of nucleic acid delivery systems.