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DOTMA (chloride)
Cat. No.:
OB0626WX-3979
Appearance:
Liquid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
DOTMA is a permanently charged cationic lipid featuring dual mono-unsaturated 18-carbon ether-linked tails. Operating as a premier classical transfection agent, this quaternary ammonium molecule forms highly stable liposomes and lipoplexes that efficiently package and deliver small interfering RNA, microRNA, and expression plasmids across cell membranes.
Synonyms:
N,N,N-trimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanaminium, monochloride; N-[1-(2,3-Dioleyloxy)propyl]-N,N,N-trimethylammonium; 104162-48-3; N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium; Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride; 104872-42-6; N,N,N-Trimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-aminium chloride; 2,3-bis[(Z)-octadec-9-enoxy]propyl-trimethylazanium;chloride; N-[1-(2,3-Dioleyloxy)propyl]-N,N,N-trimethylammonium Chloride; DOTMA Chloride; N,N,N-Trimethyl-2,3-bis[(Z)-octadec-9-en-1-yloxy]propan-1-aminium Chloride; DOTMA; 1,2-di-O-octadecenyl-3-trimethylammonium propane; 2,3-bis[(Z)-octadec-9-enoxy]propyl-trimethyl-ammonium;chloride; 1,2-di-O-octadecenyl-3-trimethylammonium propane chloride salt (DOTMA); 1-Propanaminium, N,N,N-trimethyl-2,3-bis(9-octadecenyloxy)-, chloride, (Z,Z)-; N,N,N-trimethyl-2,3-bis(((Z)-octadec-9-en-1-yl)oxy)propan-1-aminium chloride
CAS No.:
104162-48-3
Compound CID:
6438350
Formula:
C42H84NO2 • Cl
Formula Weight:
670.6
Specification
λmax:
225 nm
Solubility in DMSO:
0.5 mg/mL
Solubility in Ethanol:
30 mg/mL
Solubility in DMF:
5 mg/mL
Solubility in Other Solvents:
Ethanol:PBS mixture: 0.5 mg/mL
Storage:
Storage at -20°C.
Applications:
DOTMA (chloride) serves as a cationic lipid widely used for liposome preparation and nucleic acid delivery research. It supports formulation of lipid-based transfection systems, optimization of lipid compositions, and studies of nonviral delivery mechanisms.