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Lipid III-45
Cat. No.:
OB0626WX-3856
Appearance:
Liquid
Purity:
≥98%
Identity:
Confirmed by NMR, TLC, IR, and HPLC.
Size:
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Product Overview
Description:
Lipid III-45 is an ionizable cationic lipid possessing a pKa of 6.25, engineered to formulate responsive lipid nanoparticles for systemic transcript delivery. This amphiphilic matrix facilitates high-level cellular uptake and cargo release, directing reporter expression toward visceral and adipose tissues, while successfully delivering specialized antibody-encoding mRNA sequences to suppress tight-junction-associated tumor proliferation and reduce overall tumor volume.
Synonyms:
2-butyl-octanoic acid, 1,1′-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester; ALC-0366 Cationic Lipid A; 2096984-25-5
CAS No.:
2096984-25-5
Formula:
C45H89NO5
Formula Weight:
724.2
Specification
Solubility in Ethanol:
10 mg/mL
Storage:
Storage at -20°C.
Applications:
Lipid III-45 serves as an ionizable lipid for constructing and optimizing lipid nanoparticle formulations. It facilitates studies of nucleic acid encapsulation, formulation screening, structure–activity relationships, and characterization of lipid-mediated delivery systems.
