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IQ-3
Cat. No.:
0225LY-1067
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR.
Size:
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Product Overview
Description:
IQ3 is a JNK3-selective inhibitor (Kd: 66 nM) that also targets JNK1 and JNK2; it suppresses the production of IL-6 and TNF-α and inhibits NF-κB/AP1 transcriptional activity with an IC50 of 1.4 μM.
Synonym:
312538-03-7; [(E)-indeno[1,2-b]quinoxalin-11-ylideneamino] furan-2-carboxylate; IQ 3; 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime; IQ3; [(Z)-indeno[1,2-b]quinoxalin-11-ylideneamino] furan-2-carboxylate
CAS No.:
312538-03-7
Compound CID:
5405540
Formula:
C20H11N3O3
Formula Weight:
341.32
Specification
Targets&IC50:
JNK2: 290 nM(Kd); JNK1: 240 nM(Kd) ; JNK3: 66 nM(Kd)
Relative Density:
1.44 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
IQ-3 can be used in biochemistry to evaluate the potent and selective inhibition of JNK kinases.
Library Information
Target:
JNK
Receptor:
JNK1; JNK2; JNK3
Pathways:
MAPK signaling; Inflammation; Apoptosis
Plate Number:
AOCL-14
Plate Location:
g2
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
3.42 mg/mL; 10.02 mM
