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ARS-853
Cat. No.:
OB0225LY-0054
Appearance:
Solid
Purity:
≥97%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Size:
Product Overview
Description:
ARS-853 is a small molecule that selectively inhibits the K-Ras (G12C) mutation and exhibits antitumor activity in cell culture and animal models.
Synonym:
1629268-00-3; 1-(3-(4-((4-Chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl)glycyl)piperazin-1-yl)azetidin-1-yl)prop-2-en-1-one; 1-[3-[4-[2-[4-Chloro-2-hydroxy-5-(1-methylcyclopropyl)anilino]acetyl]piperazin-1-yl]azetidin-1-yl]prop-2-en-1-one; 2-Propen-1-one, 1-[3-[4-[2-[[4-chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl]amino]acetyl]-1-; 1-(3-(4-(2-((4-Chloro-2-hydroxy-5-(1-methylcyclopropyl)phenyl)amino)acetyl)piperazin-1-yl)azetidin-1-yl)prop-2-en-1-one
CAS No.:
1629268-00-3
Compound CID:
86279165
Formula:
C22H29ClN4O3
Formula Weight:
432.94
Specification
Relative Density:
1.357 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ARS-853 can be used for targeted therapy drug development.
Library Information
Targets:
Apoptosis; Raf; Ras
Receptors:
K-Ras(G12C)
Pathways:
MAPK; Apoptosis; GPCR/G protein
Plate Number:
AOCL-1
Plate Location:
f6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
5.5 mg/mL; 12.7 mM
