NG25

Cat. No.: OB0225WX-1756

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, HPLC, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: NG25 is a dual-targeted kinase inhibitor that suppresses the activities of both TAK1 (IC50: 149 nM) and MAP4K2 (IC50: 21.7 nM).

Synonym: 1315355-93-1; NG-25; N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide; Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-; 3-((1H-Pyrrolo[2,3-b]pyridin-4-yl)oxy)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methylbenzamide; N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methyl-3-(1H-pyrrolo(2,3-b)pyridin-4-yloxy)benzamide; N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide; N-{4-[(4-Ethylpiperazin-1-Yl)methyl]-3-(Trifluoromethyl)phenyl}-4-Methyl-3-(1h-Pyrrolo[2,3-B]pyridin-4-Yloxy)benzamide; NG 25; Bis(2,2'-bipyridine)-4,4'-dicarboxybipyridine-ruthenium di(N-succinimidyl ester) bis(hexafluorophosphate) (Technical Grade); N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide; N-{4-[(4-Ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-[(1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]benzamide

CAS No.: 1315355-93-1

Compound CID: 53340664

Formula: C₂₉H₃₀F₃N₅O₂

Formula Weight: 537.58

Specification

Targets&IC50: MAP4K2: 21.7 nM; TAK1: 149 nM

Relative Density: 1.313 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: NG25 is applied in kinase signaling experiments as a dual TAK1 and MAP4K4 inhibitor to investigate the crosstalk between TGF-beta signaling and pro-inflammatory kinase networks.