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Hispidulin
Cat. No.:
OB0626WX-1427
Appearance:
Solid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and HPLC.
Size:
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Product Overview
Description:
Hispidulin is a bioactive natural flavonoid originally derived from Arnica montana that coordinates a broad spectrum of hematological, osteogenic, and oncological modulatory activities. It downregulates thrombotic pathways by inhibiting platelet aggregation induced by PAF, arachidonic acid, and ADP, suppresses RANKL-mediated osteoclastic differentiation and bone resorption, and drives antineoplastic effects by inhibiting sphingosine kinase 1, accumulating cellular ceramide, and mitigating neuro-cognitive deficits and ischemic reperfusion injury in vivo.
Synonyms:
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; Dinatin; 6-Methoxyapigenin; 4',5,7-trihydroxy-6-methoxyflavone; 4',5,7-trihydroxy-6-methoxy-flavone; 1447-88-7
CAS No.:
1447-88-7
Compound CID:
5281628
Formula:
C16H12O6
Formula Weight:
300.3
Specification
Source:
Salvia plebeia R. Br.
λmax:
218 nm; 275 nm; 336 nm
Solubility in DMSO:
30 mg/mL
Solubility in DMF:
30 mg/mL
Solubility in Other Solvents:
DMSO:PBS mixture: 0.25 mg/mL
Storage:
Storage at -20°C.
Applications:
Hispidulin operates as a bioactive flavone reference standard utilized to profile cellular antioxidative signaling networks, evaluate transport mechanics across model barrier matrices, and analyze localized target-protein pathway modulations within complex cell culture environments.
