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HAPC-Chol
Cat. No.:
OB0626WX-3965
Appearance:
Crystalline solid
Purity:
≥95%
Identity:
Confirmed by NMR, TLC, and IR.
Size:
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Product Overview
Description:
HAPC-Chol is a cationic sterol derivative engineered to facilitate non-viral gene delivery without altering baseline cellular viability profiles. Formulated as a key structural element in multi-component lipoplexes, this molecule compacts small interfering RNA sequences to achieve robust gene silencing in vitro, while mediating distinct tissue tropism that shifts cargo distribution toward pulmonary networks upon systemic administration.
Synonyms:
(3β)-cholest-5-en-3-ol 3-[N-[3-[(2-hydroxyethyl)amino]propyl]carbamate], hydrogen iodide
Formula:
C33H58N2O3 • HI
Formula Weight:
658.7
Specification
Solubility in Ethanol:
10 mg/mL
Solubility in DMF:
10 mg/mL
Solubility in Other Solvents:
Ethanol:PBS mixture: 0.14 mg/mL
Storage:
Storage at -20°C.
Applications:
HAPC-Chol serves as a cholesterol-based cationic lipid for lipid nanoparticle formulation development and nucleic acid delivery research. It supports optimization of lipid compositions, evaluation of lipid assembly properties, and investigation of structure–activity relationships in nonviral delivery systems.