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GNB3 Blocking Peptide (DCMSLAVSPDFN)
Cat. No.:
OB0526-WX56
Origin:
Synthetic
Conjugation:
Unconjugate
Species Reactivity:
Human; Mouse; Rat; Dog; Cow
Size:
Add to basket
Product Overview
Description:
GNB3 Blocking Peptide (DCMSLAVSPDFN) is a synthetic antigenic peptide representing a specific epitope of the GNB3 protein. It is formulated to competitively inhibit the binding of compatible anti-GNB3 antibodies, allowing researchers to verify antibody specificity and assay performance. The peptide provides a practical negative control for western blotting, immunohistochemistry, and immunofluorescence applications.
Sequence:
DCMSLAVSPDFN
Molecular Weight:
1326.5 Da
Purity:
≥95%
Applications:
Western blotting; ELISA; IHC; IF; Functional Assay; Cell Culture; Binding Assay
Specification
Storage:
Storage at -20°C.
Shipping Condition:
Shipped with ice packs.
Handling Notes:
During shipping, trace amounts of the blocking peptide may adhere to the interior surface of the vial cap. Before opening, it is highly recommended to briefly centrifuge the vial to bring all contents to the bottom.
Target Profile
Full Name:
G Protein Subunit Beta 3
Alternative Names:
GNB3; GTP-Binding Regulatory Protein Beta-3 Chain; Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3; Hypertension Associated Protein; Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 3; G Protein, Beta-3 Subunit; Transducin Beta Chain 3; CSNB1H; Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 3; HG2D
Summary:
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
