ADRB2 Blocking Peptide (C-HQGTVPSDNIDSQ)

Cat. No.: OB0526-WX2

Origin: Synthetic

Conjugation: Unconjugate

Species Reactivity: Human; Dog; Cow

Size:

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Product Overview

Description: ADRB2 Blocking Peptide (C-HQGTVPSDNIDSQ) is a specific synthetic peptide used to pre-adsorb ADRB2 antibodies, eliminating non-specific background signals in immunofluorescence and IHC assays. This product provides an invaluable negative control for researchers investigating beta-2 adrenergic receptor signaling in lipolysis and energy expenditure.

Sequence: C-HQGTVPSDNIDSQ

Molecular Weight: 1556.6 Da

Purity: ≥95%

Applications: Western blotting; ELISA; IHC; IF; Functional Assay; Cell Culture; Binding Assay

Specification

Storage: Storage at -20°C.

Shipping Condition: Shipped with ice packs.

Handling Notes: During shipping, trace amounts of the blocking peptide may adhere to the interior surface of the vial cap. Before opening, it is highly recommended to briefly centrifuge the vial to bring all contents to the bottom.

Target Profile

Full Name: Beta-2 adrenergic receptor

Alternative Names: Beta-2 adrenoceptor; ADRB2R; ADRB2; B2AR; Adrenoceptor beta 2

Summary: ADRB2 encodes the beta-2-adrenergic receptor, a member of the G protein-coupled receptor superfamily. This receptor forms a signaling complex with the L-type calcium channel Ca(V)1.2, a G protein, adenylyl cyclase, cAMP-dependent kinase, and the phosphatase PP2A, which ensures precise and rapid signal transduction. ADRB2 also regulates the transcription of the alpha-synuclein gene, and variations in these genes are linked to Parkinson’s disease risk. Being intronless, ADRB2 exhibits polymorphic forms and mutations that are associated with nocturnal asthma, obesity, type 2 diabetes, and cardiovascular disease.

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