G007-LK

Cat. No.: OB0225WX-1699

Appearance: Solid

Purity: ≥98%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: G007-LK is a highly selective inhibitor of the tankyrase enzymes, demonstrating potent enzymatic suppression with IC50 values of 46 nM for TNKS1 and 25 nM for TNKS2.

Synonym: 1380672-07-0; (E)-4-(5-(2-(4-(2-chlorophenyl)-5-(5-(methylsulfonyl)pyridin-2-yl)-4H-1,2,4-triazol-3-yl)vinyl)-1,3,4-oxadiazol-2-yl)benzonitrile; 4-{5-[(E)-2-{4-(2-Chlorophenyl)-5-[5-(Methylsulfonyl)pyridin-2-Yl]-4h-1,2,4-Triazol-3-Yl}ethenyl]-1,3,4-Oxadiazol-2-Yl}benzonitrile; benzonitrile, 4-[5-[(1E)-2-[4-(2-chlorophenyl)-5-[5-(methylsulfonyl)-2-pyridinyl]-4H-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl]-; 4-[5-[(E)-2-[4-(2-chlorophenyl)-5-(5-methylsulfonylpyridin-2-yl)-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl]benzonitrile; 1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-({trans-4-[(dimethylamino)methyl]cyclohexyl}amino)-1,5-naphthyridin-3-yl]ethanone hydrochlorid e (1:1); 1AK; 4-{5-[(1E)-2-[4-(2-chlorophenyl)-5-(5-methanesulfonylpyridin-2-yl)-4H-1,2,4-triazol-3-yl]ethenyl]-1,3,4-oxadiazol-2-yl}benzonitrile

CAS No.: 1380672-07-0

Compound CID: 67960134

Formula: C₂₅H₁₆ClN₇O₃S

Formula Weight: 529.96

Specification

Targets&IC50: TNKS2: 25 nM; TNKS1: 46 nM

Relative Density: 1.47 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: G007-LK is employed in laboratory research as a high-potency tankyrase inhibitor to investigate the reduction of Wnt-mediated transcriptional activity in complex disease models.