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Ro-3306
Cat. No.:
0225LY-1081
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
RO-3306 is a selective, ATP-competitive CDK1 inhibitor (Ki: 20 nM) that demonstrates over 15-fold greater selectivity for CDK1 compared to a wide array of other human kinases.
Synonym:
872573-93-8; RO 3306; (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one; 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone; (5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylimino)-1,3-thiazolidin-4-one; (Z)-5-(Quinolin-6-ylmethylene)-2-((thiophen-2-ylmethyl)amino)thiazol-4(5H)-one; (Z)-5-(Quinolin-6-ylmethylene)-2-[(thiophen-2-ylmethyl)amino]thiazol-4(5H)-one
CAS No.:
872573-93-8
Compound CID:
135400873
Formula:
C18H13N3OS2
Formula Weight:
351.45
Specification
Targets&IC50:
CDK1: 20 nM(Ki); PKCδ: 318 nM(Ki); ERK: 1980 nM(Ki); SGK: 497 nM(Ki)
Relative Density:
1.41 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Ro-3306 can be used in cell cycle research as a potent and selective inhibitor of CDK1 to study mitotic entry.
Library Information
Target:
PKA; PKC; SGK; ERK; CDK
Receptor:
CDK; CDK1; ERK; PKA; PKCδ; SGK
Pathways:
Cytoskeletal signaling; Cell cycle/Checkpoint; Apoptosis; MAPK; Chromatin/Epigenetic; Metabolism; Tyrosine kinase/adaptors
Plate Number:
AOCL-14
Plate Location:
h7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
22.73 mg/mL; 64.67 mM
